The Raiders jumped out to a 23-0 lead early in the second quarter against the Bills, then held on to win, 26-21, in Buffalo.
In the absence of quarterback Tom Flores, who was out with a shoulder injury, Babe Parilli started at quarterback but completed just 3 of 10 passes for 82 yards and two interceptions.
Paul Larson, in relief of Parilli, made his second appearance of the preseason and completed 3 of 13 passes for 38 yards and an interception.